cpprate - Variable Selection in Black Box Methods with RelATive cEntrality (RATE) Measures

cpprate is a reimplementation of https://github.com/lorinanthony/rate in C++.

Installation

Prebuilt binaries

Prebuilt binaries are available from the releases page for linux_x86-64, macOS_x86-64, and macOS_arm64.

Compiling the cpprate executable from source

Dependencies

• cmake >= v3.1
• C++17 compliant compiler
• git >= v2.0.0

Build the cpprate executable with

mkdir build
cd build
cmake -DCMAKE_BUILD_EXECUTABLE=1 ..
make -j

API

This is a header-only library so simply include "CppRateRes.hpp" or "CppRateRes_mpi.hpp" header in your project.

Usage

Input files can optionally be compressed with gzip/bzip2/xz. The format is detected automatically.

Nonlinear coefficients

Supply the design matrix as a n_observationsxn_snps comma-separated matrix via the -x argument and the nonlinear n_posterior_drawsxn_observations comma-separated matrix via the -f argument by running

cpprate -x design_matrix_file.csv -f nonlinear_draws_file.csv

this will run the lowrank approximation by default. To run the fullrank approximation, use the --fullrank toggle (note: can be slow).

Linear coefficients

Lowrank algorithm

Supply posterior draws for the linear coefficients as a n_posterior_drawsxn_snps comma-separated matrix via the --beta-draws argument and run

cpprate -x design_matrix_file.csv --beta-draws linear_coefficients_file.tsv

Fullrank algorithm

Supply the posterior draws for the linear coefficients as a n_posterior_drawsxn_snps comma-separated matrix via the --beta-draws argument by running

cpprate --beta-draws linear_coefficients_file.csv

This will be slower than the lowrank approximation because the underlying model is the same as the fullrank model for nonlinear coefficients.

Only test certain variables

Testing all variables at once may take a long time and/or a lot of memory. To run the model on only some variables at a time, call

cpprate -x design_matrix_file.csv --beta-draws linear_coefficients_file.tsv --ids-to-test 1,2,3

This will test the first, second, and third variable. Results from several runs may be merged by merging the KLD column in the results and recalculating the RATE column as KLD[i]/sum(KLD).

Test a range of variables

A range of variable ids may be tested by calling

cpprate -x design_matrix_file.csv --beta-draws linear_coefficients_file.tsv --id-start 5 --id-end 8

This will test the 5th, 6th, 7th, and 8th variables. Results from several runs may be merged by merging the KLD column in the results and recalculating the RATE column as KLD[i]/sum(KLD).

Parallelization

cpprate can be parallelized in three ways:

• Add the number of threads via the -t argument to parallelize calculation within each SNP (many threads may result in some idling).
• Use the --ranks argument to parallelize the calculation over the SNPs (adds a slight memory overhead).
• Use both -t and --ranks to parallelize over both SNPs and within SNPs (try with test sets to figure out the optimal distribution).

If in doubt, use -t.

Development

Building tests

Build tests with

mkdir build
cd build
cmake -DCMAKE_BUILD_TESTS=1 ..
make -j

Running tests

Run tests with

bin/runTests

License

cpprate is licensed under the BSD-3-Clause license. A copy of the license is supplied with the project, or can alternatively be obtained from https://opensource.org/licenses/BSD-3-Clause.